De Soto County sits along the TN border, and contains many of Memphis's southern suburbs. Democrats have made substantial gains in recent years, but the county still leans fairly Republican. Trump won it by just short of 25 points, with Horn Lake, Southaven, and Olive Branch all at least having portions that went strongly for Kamala Harris
Lafayette County is home to the University of Mississippi/Ole Miss (in Oxford), and went for Trump by 22 points in 2024. Democrats did best in the majority African American communities surrounding Oxford, but the city itself and the surrounding areas still keep the county fairly red